dimethylformamide toxicity

SIGMA

N N-Dimethylformamide CAS-No 68-12-2 Revision Date 2007-07-01 Pennsylvania Right To Know Components N N-Dimethylformamide CAS-No 68-12-2 Revision Date 2007-07-01 New Jersey Right To Know Components N N-Dimethylformamide CAS-No 68-12-2 Revision Date 2007-07-01 California Prop 65 Components

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Reproductive toxicity

Reproductive toxicity -- N N-Dimethylformamide: Introduction Reproductive toxicity -- N N-Dimethylformamide: N N-Dimethylformamide is a suspected reproductive toxicant and exposure to it has the potential to negatively affect the human reproductive system N N-Dimethylformamide is used mainly as a solvent in the manufacture of acrylic fiber and a separating agent in latex production

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Greener Alternatives to Dimethylformamide Use in

Dec 17 2019developmental toxicity endocrine activity acute mammalian toxicity systemic toxicities neurotoxicity skin/eye irritation and corrosivity (based on classification in the Pharos database [Pharos 2019]) Overall DMF is a high or moderate hazard for the endpoints of carcinogenicity

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N N

N N-Dimethylformamide Structure: C3H7NO Synonyms • Dimethylamid Kyseliny Mravenci (Czech) • Dimethylformamid (German) • Dimethyl Formamide • N N-Dimethyl Formamide • Dimethylformamide • N N-Dimethylmethanamide • Dimetilformamide (Italian) Toxicity Toxicity Data • ORL-RAT LD50: 2800 MG/KG • IPR-RAT LD50: 1400 MG/KG

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Toxic Substances Portal

Sep 26 2019The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties Other pertinent literature is also presented but is described in less detail than the key studies

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dimethylformamide

Toxicity: Organic Compound Solvent Amine Amide Pollutant Food Toxin Metabolite Industrial/Workplace Toxin Synthetic Compound Toxin Toxin-Target Database T3D0252 ORL-RAT LD50 2800 mg kg-1 IPR-RAT LD50 1400 mg kg-1 IVN-RAT LD50 2000 mg kg-1 IPR-RBT LD50 1000 mg kg-1 OU Chemical Safety Data (No longer updated) More details

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Clinical and Pathological Characteristics of

intended to prove which toxic exposure caused the liver disease described: the epidemiologic clinical and industrial hygiene data previously reported (9) provide strong evidence that the liver disease ob- served in these workers was caused by toxic exposure at this workplace most likely dimethylformamide

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Dimethylformamide metabolism following self

Mraz Jaroslav Jheeta Parmjit Gescher Andreas Hyland Ruth Thummel Kenneth Threadgill Michael D Investigation of the mechanistic basis of N N-dimethylformamide toxicity Metabolism of N N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1 10 1021/tx00032a009

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Dimethylformamide H

1 Toxic Effects and Modes of Action Dimethylformamide (DMF) is a solvent which is readily absorbed and distributed in the body during inhalation of the substance or dermal exposure Considerable experience of human exposure and the results of animal studies indicate that the liver is the predominant target organ of dimethylformamide toxicity

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N N

N N-Dimethylformamide Structure: C3H7NO Synonyms • Dimethylamid Kyseliny Mravenci (Czech) • Dimethylformamid (German) • Dimethyl Formamide • N N-Dimethyl Formamide • Dimethylformamide • N N-Dimethylmethanamide • Dimetilformamide (Italian) Toxicity Toxicity Data • ORL-RAT LD50: 2800 MG/KG • IPR-RAT LD50: 1400 MG/KG

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Material Safety Data Sheet DIMETHYL SULFOXIDE

DIMETHYL SULFOXIDE PAGE 2 of 5 cause liver and kidney damage Effects may be delayed Avoid contact with Dimethyl Sulfoxide (DMSO) solutions containing toxic materials or materials with unknown toxicological properties DMSO is readily absorbed through skin and may carry such materials into the body Hygroscopic – moisture sensitive Possible

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What is a LD50 and LC50? : OSH Answers

LD stands for Lethal Dose LD 50 is the amount of a material given all at once which causes the death of 50% (one half) of a group of test animals The LD 50 is one way to measure the short-term poisoning potential (acute toxicity) of a material Toxicologists can use many kinds of animals but most often testing is done with rats and mice It is usually expressed as the amount of chemical

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Material Safety Data Sheet

This material contains N N-Dimethylformamide (CAS# 68-12-2 99+%) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Clean Air Act: CAS# 68-12-2 is listed as a hazardous air pollutant (HAP) This material does not contain any Class 1 Ozone depletors

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N N

Thera ware never any noticeable toxic effects when calls ware cultured in the presenceof 0 8% DMF When dishes containing DMF-traatad colon carcinoma calls reach con fluency and the cells are harvested the viability of treated calls is greater than 95% as measured by trypan blue dye exclusion This is a better viability than that obtained from

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Subchronic inhalation toxicity of dimethylformamide in

Fisher F344 rats and B6C3F1 mice were exposed to concentrations of 0 150 300 600 and 1200 ppm of dimethylformamide (DMF) for 6 hours a day 5 days a week for 12 weeks Detailed clinical observations were obtained weekly and body weights biweekly on all animals

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X

X-GAL (20MG/ML)(W/V) SOLUTION IN DIMETHYLFORMAMIDE Safety Data Sheet according to Federal Register / Vol 77 No 58 / Monday March 26 2012 / Rules and Regulations 07/24/2014 EN (English US) 2/6 2 3 Other hazards No additional information available 2 4 Unknown acute toxicity (GHS-US) No data available

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WikiGenes

CONCLUSIONS: an outbreak of toxic liver disease has been associated with exposure to dimethylformamide in the workplace The human acute promyelocytic leukemia cell line HL-60 is induced by retinoic acid (RA) and N N-dimethylformamide (DMF) to differentiate into cells having many of the functional and morphologic characteristics of mature

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1 Identification

Acute Inhalation Toxicity - Vapors Category 4 Emergency Telephone Number CHEMTREC Inside the USA: 800-424-9300 CHEMTREC Outside the USA: 001-703-527-3887 Serious Eye Damage/Eye Irritation Category 2 Revision Number 1 Reproductive Toxicity Category 1B Creation Date 03-Sep-2009 Specific target organ toxicity (single exposure) Category 3

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