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tosylate 4-Methylbenzenesulfonate Toluene-4-sulfonate 4-Toluenesulfonate 4-Toluene sulfonate More Molecular Weight: 171 2 g/mol Parent Compound: CID 6101 (P-Toluenesulfonic acid) Dates: Modify: 2020-06-06 Create: 2005-07-11 Toluene-4-sulfonate is an arenesulfonate oxoanion that is the conjugate base of toluene-4-sulfonic acid It is a conjugate base of a toluene-4-sulfonic acid

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Activity

1-(Ethoxyhydroxyphosphinyl)-10-undecene (5) A solution of compound 4 (0 31 g 1 07 mmol 1 0 equiv) in CH 2 Cl 2 (4 0 ml 0 3 M) was treated dropwise with trimethylsilyl bromide (0 17 ml 1 28 mmol 1 2 equiv) The reaction was stirred at 25C for 1 h quenched with 5 ml of 5% [wt/vol] KHSO 4 and stirred vigorously for 5 min The reaction mixture was then partitioned between ethyl acetate

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Requirements the School of Chemistry August 1974

Tosylate Derivitives 25 7 Inductive Substituent Constants • • • • • • • 28 8 Alkaline Hydrolysis of ESter (XXXVIII) in 50 Percent (Weight) Aqueous Ethanol at 25C 66 9 The CalcUlation of pKa of Tricyclo-[3 2 2 0 2 4 exo]- nontuai--exo-earborylic Adid by the Henderson aasselbach Equation 72 10 Solvolysis of Tosylates

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Tosylate – Wikipedia

Sorafenib tosylate Drug Entry Sorafenib Sorafenib (rINN) marketed as Nexavar by Bayer is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer) It has also received Fast Track designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer) and has since performed well in Phase III trials Sorafenib is a small

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PhysChem ADME/Tox Calculations

Read how Percepta helps chemists and formulators work more efficiently and assists in decision-making Watch on Demand Article Determination of acid dissociation constants (pKa) of cephalosporin antibiotics: Computational and experimental approaches Comparison of experimental and published pK a values for 88 cephalosporin antibiotics with ACD/pK a and other prediction software Read more

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Tosylgruppe – Wikipedia

Edoxaban tosylate monohydrate Drug Entry Edoxaban Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs and is a rapidly acting oral selective factor Xa inhibitor By inhibiting factor Xa a key protein in the coagulation cascade edoxaban prevents the stepwise amplification of protein factors needed to form blood clots It is indicated to reduce the risk of stroke

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Mitsunobu and Related Reactions: Advances and

diethyl azodicarboxylate (DEAD) or diisopropyl azodicar-boxylate (DIAD) Given below are some of the salient features of this reaction: (i) The substrates are primary or secondary alcohols Chiral secondary alcohols undergo a complete in- Version of configuration unless sterically very congested 40-42 This aspect has been positively exploited in numerous reactions

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Protecting Groups in Organic Synthesis

Protecting Groups in Organic Synthesis-2 Ready Brook Rearrangement bond BDE (kcal/mol) CSi OSi FSi 69 103 141 question: using approx pKa values and the BDE above estimate Keq for different R's in the equation 1 O X R SiR 3 _ OSiR 3 X R _ Ph O OtBu HO SiMe 2 tBu DBU DMSO Ph O OtBu OTBS TL 1998 5243 O O SiMe 2tBu Li O SiMe 2tBu LiO

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PKA inhibitor

Chemsrc provides PKA inhibitor's classification including all chemical products obtained by chemical processes (chemical methods to change the composition or structure of substances or to synthesize new substances all of which belong to chemical production techniques)

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Identification of Functional MKK3/6 and MEK1/2 Homologs

Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and In Vivo Chuanshan Zhang # a b Jing Li # c Tuerganaili Aji # d Liang Li a Xiaojuan Bi a Ning Yang a Zhide Li b Hui Wang a Rui Mao e Guodong L a Yingmei Shao d Dominique A

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Nu + L Nucleophile substrate (Leaving group L)

Nucleophile substrate (Leaving group L) conditions Nucleophiles are chemical species that react with centers of positive ionic character When the center is an aliphatic carbon the process is called aliphatic nucleophilic substitution Chemical reactions of this type are extremely important for the synthesis of new compounds and for understanding the mechanisms in organic chemistry All

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Formulation Diary

Solubility is pH independent below the pKa of 9 95 Water Solubility: With an aqueous free base solubility of 0 7 mg/mL to 1 1 mg/mL across the physiological pH range: Each ZEJULA capsule contains 159 4 mg niraparib tosylate monohydrate equivalent to 100 mg niraparib free base as the active ingredient

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Formulation Diary

pKa (Strongest Acidic) 14 03 (Predicted) pKa (Strongest Basic) 10 1 (Predicted) Log P: 2 45 (Predicted) Identification: HPLC) Degradation: Forced degradation studies were carried out by exposing the active substance to heat light acid base and oxidative conditions Niraparib tosylate monohydrate is stable in the solid state and did not show significant degradation in basic/acidic aqueous

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T3DB: S

S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body It is a direct metabolite of the essential amino acid L-methionine SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation

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Mesoporous Silica Nanoparticles: A Comprehensive Review

06 08 2018On changing the counter ion to a much larger tosylate ion When the pH fell below the pKa of the stalk the interaction between p-anisidine and β-CD reduced thus resulting in the release of the drug An optimum density of the stalk was the key to control the pH-triggered release In addition the effect of both α and β-CD capping on the release of drug was studied It was observed that

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FDA Approval Summary: Niraparib for the Maintenance

physiologic pH range of 1 0 to 6 8 at 37 C (niraparib tosylate pKa 9 95) Niraparib is approved as 100-mg capsules for oral administration which is equivalent to 159 4 mg of niraparib tosylate monohydrate The approved dose is three capsules once daily for a total dose of 300 mg Nonclinical Pharmacology and Toxicology In vitro niraparib inhibited isoforms of PARP including PARP-1 and

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DailyMed

Mar 23 2020DailyMed provides trustworthy information about marketed drugs in the United States DailyMed is the official provider of FDA label information (package inserts) This Web site provides a standard comprehensive up-to-date look-up and download resource of medication content and labeling found in medication package inserts

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1 1 1 3 3 3

The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds It involves two reagents with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate normally an unsaturated halide tosylate or similar -

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Introduction to Sulfur Functional Groups

Tosylate (p-toluenesulfonate) ion CH 3 C 6 H 4 SO 2 O-Besylate (benzenesulfonate) ion C 6 H 5 SO 2 O-The preceding terms apply to salts and esters as well as anions Sulfonic Acid Chlorides Sulfonic acid chlorides are a class of organic compounds with the general formula R-SO 2-Cl These compounds react readily with alcohols to sulfonic

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