gaba shunt in plants

Discovery to help wheat cope with salty soils

The bypass system identified by the researchers called the 'GABA shunt' allows wheat plants to stop using one of their salt-sensitive enzymes when threatened by saline soil However the resistance provided by the GABA shunt also appears to have a limit and is overpowered by especially saline soils

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gamma

Much of the recent work on the γ-aminobutyrate (GABA) shunt in plants has concentrated on stress/pest-associated and signalling roles However fifty years after the structural elucidation of the pathway aspects of its regulation and even of its biological significance remain largely obscure Here we assess the importance of GABA metabolism in plants reviewing relevant biological

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GABA

-Aminobutyric Acid Vaibhav Jain Contents Introduction Historical Overview Metabolism of GABA GABA Receptors Signal Transduction Pharmacology Clinical Aspects Conclusion Introduction-Amino butyric acid or GABA is the most ubiquitous inhibitory neurotransmitter in the brain expressed in about 30% of all synapses GABA is a four Carbon amino acid found mostly as a zwitterion i e with the

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BAT1

May play a role in primary carbon metabolism and plant growth by mediating the transport of GABA from the cytosol to mitochondria When expressed in a heterologous system (yeast) imports Arg and Ala across the plasma membrane and exports Lys and Glu but does not transport proline

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Is there a room for GABA in ROS and RNS signalling?

Highlights•GABA is a non-protein amino acid found in almost all organisms including plants •GABA-shunt is the anabolic and catabolic reactions with highly conserved components •An indirect interaction between GABA and ROS and RNS signalling might take place •A plausible interaction for ROS GABA might be via the new PTM "succinylation" •In case of RNS the interacting with GABA

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Abstract 5486: The role of the GABA shunt in prostate

Proceedings: AACR Annual Meeting 2018 April 14-18 2018 Chicago IL The GABA (γ-aminobutyric acid) shunt a bypass mechanism for a portion of the tricarboxylic acid (TCA) cycle is responsible in the mammalian central nervous system for the synthesis and degradation of the inhibitory neurotransmitter GABA Glutamic acid decarboxylase (GAD67 and GAD65 gene names GAD1 and GAD2

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Succinic acid

Succinic acid (/ s ə k ˈ s ɪ n ɪ k /) is a dicarboxylic acid with the chemical formula (CH 2) 2 (CO 2 H) 2 The name derives from Latin succinum meaning amber In living organisms succinic acid takes the form of an anion succinate which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the

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Concurrent overactivation of the cytosolic glutamine

Temporal alterations in the GABA shunt GS/GOGAT cycle and phenylpropanoid pathway were transcriptionally enzymatically and metabolically monitored in both wild-type and sitiens plants Virus induced gene silencing microscopic analyses and pharmacological assays were used to further confirm the data Our results on the sitiens-B cinerea interaction favor a model in which cell viability in

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In higher plants GABA is primarily metabolized via a short pathway called the GABA shunt The GABA shunt bypasses two steps (the oxidation of α-ketoglutarate to succinate) of the tricarboxylic acid (TCA) cycle via reactions catalyzed by three enzymes: glutamate decarboxylase GABA transaminase and succinic semialdehyde dehydrogenase The GABA shunt plays a major role in primary carbon and

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Suppression of g

GABA content in the stems of the 35S::SlGABA-TRNAi lines was also higher than that in the WT plants The GABA content in 35S::SlGABA-T1RNAi lines No 1 2 and 23 corresponded to a 10 1- 8 0- and 11 7-fold increase respectively over that in WT plants (Fig 3A) However the stem GABA content in SlGABA-T2RNAi and SlGABA-T3RNAi lines remained

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Revealing Different Systems Responses to Brown

Brown planthopper (BPH) is a notorious pest of rice plants attacking leaf sheaths and seriously affecting global rice production However how rice plants respond against BPH remains to be fully understood To understand systems metabolic responses of rice plants to BPH infestation we analyzed BPH-induced metabolic changes in leaf sheaths of both BPH-susceptible and resistant rice varieties

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PUBLICATIONS

PUBLICATIONS (Google Citation Index) H Fromm H Y Fichman Y (2019) Water sensing in plants In: (2008) Highway or byway: the metabolic role of the GABA shunt in plants Trends in Plant Science 13 14-19 O Van Aken K Morreel B Vandecotte H Fromm W Boerjan D Inze and F Van Breusegem (2007) Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting

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Regulation of plant fertility by modulation of GABA levels

The invention provides methods for the alteration of fertility in plants through modulation of floral GABA levels The techniques of the invention may find use in plant breeding techniques Also provided by the invention are assays for the screening of candidate modulators of GABA metabolism or GABA analogs through the identification of affects on fertility following application of the

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Functional analysis of rice GABA shunt that responds to

In order to investigate function of gamma-aminobutyric acid (GABA) shunt in response to abiotic stresses we established various kinds of transgenic rice lines that overexpress a gene for GABA aminotransferase (GABA -T) or glyoxylate reductase These transgenic rice plants were subjected to abiotic stresses such as low temperature salt drought and hydrogen peroxide (200 mM)

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Contribution of the GABA shunt to hypoxia

01 01 2008Abstract When subjected to low oxygen stress plants accumulate alanine and γ-aminobutyric acid (GABA) To investigate the function of GABA metabolism under hypoxia and its contribution to alanine accumulation we studied the genes that encode the two key enzymes of the GABA shunt glutamate decarboxylase (GAD) and GABA transaminase (GABA-T)

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PROLINE AND GABA AS ANTIOXIDANTS

BIOSYNTHESIS OF GABA GABA shunt reactions are responsible for the synthesis conservation and metabolism of GABA GABA-T GABA α-oxoglutarate transaminase GAD glutamic acid decarboxylase SSADH succinic semialdehyde dehydrogenase 18 GABA SHUNT PATHWAY • In cytosol glutamate decarboxylase(GAD) catalyses glutamate to GABA •GABA is transported from cytosol to

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Signaling mechanisms integrating carbon and nitrogen

Fig 2 GABA shunt pathway is critical in coordinating C and N metabolism Carbon skeletons used for N assimilation are mainly from TCA cycle in mitochondria while chloroplast is the place in which N is assimilated into glutamate Glutamate is decarboxylated into GABA by GAD in cytosol GAD is the key limitation enzyme in the GABA shunt pathway Regulation of GAD might be critical in balancing

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Field trial of GABA

We previously produced GABA-fortified rice lines of a popular Japonica rice cultivar 'Koshihikari' by genetic manipulation of GABA shunt-related genes In the study reported here we grew these same novel rice lines in a field trial and administered the milled rice orally to rats The yield parameters of the transgenic rice plants were almost unchanged compared to those of untransformed cv

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Axit gamma

gamma-Aminobutyric acid hoặc axit γ-aminobutyric / ˈ ɡ m ə ə ˈ m iː n oʊ b juː ˈ t ɪr ɪ k ˈ s ɪ d / hoặc GABA / ˈ ɡ b ə / l chất ức chế dẫn truyền thần kinh chnh trong hệ thống thần kinh trung ương động vật c v trưởng thnh pht triển Vai tr chnh của n l lm giảm sự kch thch thần kinh trong ton

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GABA in plants: just a metabolite?

The GABA shunt is a conserved pathway in eukaryotes and prokaryotes but although the role of GABA as a neurotransmitter in mammals is clearly established its role in plants is still vague albeit with increasing evidence for its importance in various aspects of plant development metabolism and responses to stress GABA probably plays a dual role as both a signaling molecule and a metabolite

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gamma

Gamma-aminobutyric acid was first synthesized in 1883 and was first known only as a plant and microbe metabolic product In 1950 however GABA was discovered to be an integral part of the mammalian central nervous system [44] Synthesis GABA does not penetrate the blood–brain barrier it is synthesized in the brain It is synthesized from glutamate using the enzyme L-glutamic acid

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BAT1

May play a role in primary carbon metabolism and plant growth by mediating the transport of GABA from the cytosol to mitochondria When expressed in a heterologous system (yeast) imports Arg and Ala across the plasma membrane and exports Lys and Glu but does not transport proline

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